Detecting non-coding selective pressure in coding regions
Open Access
- 1 January 2007
- journal article
- research article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 7 (Suppl 1) , S9
- https://doi.org/10.1186/1471-2148-7-S1-S9
Abstract
Comparative genomics approaches, where orthologous DNA regions are compared and inter-species conserved regions are identified, have proven extremely powerful for identifying non-coding regulatory regions located in intergenic or intronic regions. However, non-coding functional elements can also be located within coding region, as is common for exonic splicing enhancers, some transcription factor binding sites, and RNA secondary structure elements affecting mRNA stability, localization, or translation. Since these functional elements are located in regions that are themselves highly conserved because they are coding for a protein, they generally escaped detection by comparative genomics approaches.Keywords
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