Metabolism of toluene in man: gas-chromatographic determination of o-, m- and p-cresol in urine
- 1 December 1979
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 43 (2) , 93-98
- https://doi.org/10.1007/bf00333615
Abstract
Complete separation of phenol, o-, m- and p-cresol was achieved by capillary gas-chromatography. Urinary concentrations of cresols were determined quantitatively in samples from 10 male workers exposed to toluene. Besides pcresol, o- and m-cresol were found to be urinary compounds in the case of the exposed group in contrast to normal persons. This finding was proved by gas-chromatography/mass spectrometry. The difference between both groups is significant. It is concluded that besides hippuric acid o-, m- and p-cresol are metabolites of toluene.Keywords
This publication has 9 references indexed in Scilit:
- Chronische lösungsmittelbelastung am arbeitsplatzInternationales Archiv für Arbeitsmedizin, 1979
- Occupational chronic exposure to organic solventsInternationales Archiv für Arbeitsmedizin, 1979
- Experimental human exposure to tolueneInternationales Archiv für Arbeitsmedizin, 1979
- Chirale Polysiloxane zur Trennung von optischen AntipodenAngewandte Chemie, 1978
- Rapid Gas Chromatographic Separation of Amino Acid Enantiomers with a Novel Chiral Stationary PhaseJournal of Chromatographic Science, 1977
- Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compoundsCellular and Molecular Life Sciences, 1972
- Fluorometric Microanalysis of Plasma Hippuric Acid and Comparison of Hippurate with P-Aminohippurate Clearances in Dogs.Experimental Biology and Medicine, 1964
- Tables for use in comparisons whose accuracy involves two variances, separately estimated.1949
- TABLES FOR USE IN COMPARISONS WHOSE ACCURACY INVOLVES TWO VARIANCES, SEPARATELY ESTIMATEDBiometrika, 1949