Directional Positive Selection on an Allele of Arbitrary Dominance
Open Access
- 1 January 2006
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 172 (1) , 713-718
- https://doi.org/10.1534/genetics.105.044065
Abstract
Most models of positive directional selection assume codominance of the beneficial allele. We examine the importance of this assumption by implementing a coalescent model of positive directional selection with arbitrary dominance. We find that, for a given mean fixation time, a beneficial allele has a much weaker effect on diversity at linked neutral sites when the allele is recessive.Keywords
This publication has 35 references indexed in Scilit:
- THE SIGNATURE OF POSITIVE SELECTION ON STANDING GENETIC VARIATIONEvolution, 2005
- A Pseudohitchhiking Model of X vs. Autosomal DiversityGenetics, 2004
- Ancestral inference on gene trees under selectionTheoretical Population Biology, 2004
- SelSim: a program to simulate population genetic data with natural selection and recombinationBioinformatics, 2004
- A common framework for understanding the origin of genetic dominance and evolutionary fates of gene duplicationsTrends in Genetics, 2004
- Patterns of Microsatellite Variability Among X Chromosomes and Autosomes Indicate a High Frequency of Beneficial Mutations in Non-African D. simulansMolecular Biology and Evolution, 2004
- Human disease genesNature, 2001
- Detection of the Signature of Natural Selection in Humans: Evidence from the Duffy Blood Group LocusAmerican Journal of Human Genetics, 2000
- The effect of hitch-hiking on neutral genealogiesGenetics Research, 1998
- On the number of segregating sites in genetical models without recombinationTheoretical Population Biology, 1975