Über die Stellung der Urokaninsäure im Histidinstoffwechsel

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Abstract
In the animal body, histidine was attacked by the enzyme histidase. The first product formed was unstable and in alkaline soln. was converted into optically active glutamic acid. Since, when histidine was fed to dogs, urocanic acid was recovered in the urine, it was concluded that urocanic acid was a normal intermediate metabolism product of histidine. In the livers of cats and rabbits, through the action of Edlbacher''s histidase, histidine was readily converted into urocanic acid, which was changed into d,l-isoglutamine by the action of a special enzyme. In the liver, 1-isoglutamine was probably changed to 1(+ )-glutamic acid. It was sug-gested that the conversion in the body of histidine into urocanic acid was an "intramolecular deamination.

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