Preparation and biological activities of 10-decarbamoyloxy-9-dehydromitomycin b and its analogs.

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Abstract
A new naturally occurring mitomycin, 10-decarbamoyloxy-9-dehydromitomycin B (1), was prepared by treating mitomycin B with sodium hydride. Its analogs having an exo-cyclic double bond in their structure were also synthesized. These compounds showed antibacterial and cytotoxic activities. Among them, 7-amino-10-decarbamoyloxy-9-dehydro-7-demthoxymitomycin B (2) was the most potent growth inhibitor of [human oral carcinoma] KB cells in vitro and, accordingly, it appears to be a potential antitumor agent.

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