Renal Clearance of P-Aminohippuric Acid and Inulin in Dairy Cattle

Publisher Website
Google Scholar
Abstract
Studies were made on four dairy cows to determine if p-aminohippuric acid (PAH) and inulin could be used to obtain reliable kidney clearances. The extent of conjugation and the conjugation products of PAH were ascertained. Recovery of p-aminophippuric acid and inulin in the urine of the four experimental cows during a period of 10 hr. or longer after injection averaged 92 and 82% of the injected doses. The results of these experiments indicate that PAH and inulin can be used, with a single intravenous injection into a cow, to give reliable data for the calculation of kidney clearances of these chemicals. The single intravenous injection of the test chemicals and calculation of the mean serum concentration from the serum decay curve-kinetic type data is much simpler and is a distinct advantage over giving a primary dose and continuous infusion during the clearance period, especially in large animals. The PAH and inulin clearances are generally considered to measure effective renal plasma flow and glomerular nitration rate, respectively. Copyright © 1968. American Society of Animal Science . Copyright 1968 by American Society of Animal Science