Neuronal and extraneuronal uptake of L-3H-adrenaline and L-14C-noradrenaline in the fish spleen

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Abstract
The neuronal and extraneuronal uptake of adrenaline [epinephrine] and noradrenaline [norepinephrine] in the isolated perfused spleen of the cod was studied using radiolabeled amines. The neuronal uptake of adrenaline shows an optimum at 0.5 .mu.g/ml, but is less efficient than noradrenaline in the concentration range 0.01-2.5 .mu.g/ml. The neuronal uptake of noradrenaline accounts for 60-70% of the total (neuronal plus extraneuronal) uptake in the concentration range 0.01-1.0 .mu.g/ml. At higher concentrations (2.5-5.0 .mu.g/ml) the importance of the extraneuronal uptake increases for both amines, to reach more than 90% of the total uptake at 5.0 .mu.g/ml. The extraneuronal uptake shows equal efficiency for the 2 amines. The cod spleen possesses a neuronal uptake mechanism which shows a higher uptake efficiency for noradrenaline than for adrenaline, while the extraneuronal uptake mechanism shows no preference.

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