Collagen Gels: Design for a Vitreous Replacement

13 June 1969

journal article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 164 (3885) , 1282-1283
https://doi.org/10.1126/science.164.3885.1282

Abstract

Clear, stable gels have been prepared from purified tropocollagen from calf skin; the collagen was solubilized with a proteolytic enzyme (Proctase) and stabilized by ultraviolet irradiation under nitrogen. These gels are clear, possess altered immunologic reactivity, and have properties of an ideal vitreous replacement. Implantations in rabbit and monkey eyes appear to be well tolerated, remain clear, and gradually disappear in about 2 months.

Keywords

NITROGEN

This publication has 5 references indexed in Scilit:

Collagen-Derived Membrane: Corneal Implantation
Science, 1967
THE SEROLOGIC SPECIFICITY OF TROPOCOLLAGEN TELOPEPTIDES
The Journal of Experimental Medicine, 1967
Effects of Pepsin Treatment on the Interaction Properties of Tropocollagen Macromolecules^*
Biochemistry, 1965
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Proceedings of the National Academy of Sciences, 1964
Tropocollagen: Significance of Protease-Induced Alterations
Science, 1963