Production of a polar metabolite of 1,25-dihydroxyvitamin D3 in a rat liver perfusion system
- 1 March 1981
- journal article
- research article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 26 (3) , 242-246
- https://doi.org/10.1007/bf01391637
Abstract
When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results in no formation of the polar metabolite. These data suggest that a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver prior to being excreted in bile. Moreover, it is likely that polar metabolites of 1,25-dihydroxyvitamin D3 present in the bile of ratsin vivo are formed in the liver.Keywords
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