The Inability of Neisseria gonorrhoeae Pili Antibodies to Confer Immunity in Subcutaneous Guinea-pig Chambers

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Abstract
Immunoelectron microscopy using rabbit antisera showed that pili of different strains of N. gonorrhoeae are antigenically heterogeneous with cross-reactions occurring only rarely. Whether serological cross-reaction in pili reflects cross-protection in the guinea pig model was investigated. If correlation between the serological behavior of pili and protection exists, the specificity of pili antibodies could be used for the screening of strains suitable for vaccines.