Ultra‐short metformin pretreatment for clomiphene citrate‐resistant polycystic ovary syndrome
- 25 May 2005
- journal article
- research article
- Published by Wiley in International Journal of Gynecology & Obstetrics
- Vol. 90 (1) , 39-43
- https://doi.org/10.1016/j.ijgo.2005.04.004
Abstract
To evaluate the effect of ultra-short (12 days) metformin pretreatment in clomiphene-citrate (CC) resistant polycystic ovary syndrome (PCOS). Eighty women with CC-resistant PCOS were randomly allocated to metformin pretreatment or usual treatment. Forty women received 1500 mg metformin daily for 12 days, followed by clomiphene 150 mg daily for 5 days along with metformin. Forty women (control group) received the same dose of clomiphene but no metformin pretreatment. In the metformin group, 17 (42.5%) women ovulated, and 6 (15%) conceived. In the control group, 5 (12.5%) women ovulated but none conceived. Compared with the control group, the metformin group had significantly higher ovulation (P = 0.03) and pregnancy rates (P = 0.026). Twelve days of metformin pretreatment improves ovulation and pregnancy rates in women with CC-resistant PCOS.Keywords
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