RELEASE OF PROSTAGLANDIN‐LIKE SUBSTANCES BY SHIGELLA ENDOTOXIN AND ITS INHIBITION BY NON‐STEROIDAL ANTI‐INFLAMMATORY COMPOUNDS

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Abstract
1 The effects of intravenous and intraocular injections of Shigella endotoxin on the inflammatory response, the release of prostaglandin-like substances into the aqueous humour, and the effects of indomethacin on the inflammatory response were studied in the rabbit eye. 2 Both intravenous and intraocular injection of endotoxin released 12.8 ng to 72 ng of prostaglandin-like substances per ml of aqueous humour and increased the permeability of the blood-aqueous barrier as shown by the rise in aqueous humour protein (26–52 mg protein/ml of aqueous humour). 3 Indomethacin, 0.25% administered topically completely inhibited the release of prostaglandin-like substances but was found to have inconsistent inhibitory effects on the clinical signs of inflammation and on the blood-aqueous barrier. Indomethacin was less effective in eyes receiving the higher dose of endotoxin. 4 It is suggested that prostaglandins and possibly other chemical mediators are involved in endotoxin-induced ocular inflammation.