Human histone genes map to multiple chromosomes.
- 1 May 1986
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 83 (10) , 3185-3188
- https://doi.org/10.1073/pnas.83.10.3185
Abstract
Histone genes were mapped to at least three human chromosomes by Southern blot analysis of DNAs from a series of mouse-human somatic cell hybrids (using 32P-labeled cloned human histone DNA as probes). Chromosome assignment was confirmed by in situ hybridization of radiolabeled histone gene probes (3H-labeled) to metaphase chromosomes. One human histone gene cluster (.lambda. HHG41) containing an H3 and H4 gene resides only on chromosome 1, whereas other clusters containing core (H3, H4, H2A, and H2B) alone (.lambda. HHG17) or core together with H1 histone genes (.lambda.HHG415) have been assigned to chromosomes 1, 6, and 12. These results suggest that the multigene family of histone coding sequences that reside in a series of clusters may be derived from a single cluster containing one each of the genes for the five principal classes of histone proteins. During the course of evolution, a set of events, probably involving reduplication, sequence modification, and recombination, resulted in the present pattern of human histone gene distribution among several chromosomes.This publication has 19 references indexed in Scilit:
- Coordinate replication of members of the multigene family of core and H1 human histone genes.Proceedings of the National Academy of Sciences, 1984
- A Major Human Histone Gene Cluster on the Long Arm of Chromosome 1Science, 1984
- Variations in the organization of human genomic DNA segments containing H1 histone genesBiochemical and Biophysical Research Communications, 1984
- Clustering of Human H1 and Core Histone GenesScience, 1984
- Evidence for a human histone gene cluster containing H2B and H2A pseudogenes.Proceedings of the National Academy of Sciences, 1984
- Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cellsNucleic Acids Research, 1983
- Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.Molecular and Cellular Biology, 1983
- Genes Coding for Histone Proteins in Man Are Located on the Distal End of the Long Arm of Chromosome 7Science, 1979
- The Localization of the Genes Coding for Histone H4 in Human ChromosomesCold Spring Harbor Symposia on Quantitative Biology, 1978
- The Organization of the Histone Genes in Drosophila melanogaster: Functional and Evolutionary ImplicationsCold Spring Harbor Symposia on Quantitative Biology, 1978