EFFECTS OF SARCOIDOSIS ON PULMONARY FUNCTION WITH PARTICULAR REFERENCE TO CHANGES IN PULMONARY COMPLIANCE

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Abstract
Physiologic studies of respiration were carried out in 16 young ment with pulmonary sarcoidosis. Fifteen of these patients had minimal symptoms or were asymptomatic. Most measurements of lung volume, forced ventilation, and blood gases at rest were within normal limits. Pulmonary compliance, however, was decreased to 0.114 [plus or minus] 0.051 of water. There was a significant relationship between compliance and vital capacity, between compliance and the extent of abnormality in vital capacity, and between compliance and change in arterial O2 tension during exercise. Data indicate that change in pulmonary elastic properties is detectable before other physiologic attributes have become abnormal or subjective symptoms have become a presenting complaint.