The Metabolism of Indium After Administration of a Single Dose to the Rat by Intratracheal, Subcutaneous, Intramuscular and Oral Injection

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Abstract
Distribution and excretion of indium after four routes of administration were studied by counting the gamma-activity of tissues from rats injected with tracer amounts of indium-114m. In 4 days over half the administered dose was absorbed from the injection sites in all but the oral route where absorption was in the order of 0.5 per cent of the administered dose. A general distribution of the isotope was seen after all routes studied, with kidney, spleen, liver and salivary glands containing higher concentrations. Pelt, skeleton and muscle contained the largest absolute amounts of indium, and of these three skeleton had the highest concentration. Excretion of indium, with the exception of the oral route, was essentially independent of route of administration, occurring with an early rapid phase and a long slow phase which approximated a single exponential after about 20 days. At 30 days after administration 33–40 per cent of the administered dose had been eliminated from the body in urine and feces. Urinary excretion data after all but the oral route were so similar that they were treated statistically as one population and may form the basis for a reliable bio-assay method utilizing analysis of daily urine samples.

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