Serum levels of insulin‐like growth factor (IGF) I, II and IGF binding protein in diabetic adolescents treated with continuous subcutaneous insulin infusion

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Abstract
IGF‐I and IGF‐II as well as the low molecular type of IGF binding protein (IGFPB) were determined in serum from 11 adolescents with insulin‐dependent diabetes mellitus (IDDM) during a cross‐over study with conventional and continuous subcutaneous insulin infusion (CIT and CSII) therapy. At the onset of the study the mean IGF‐I level, 127 ± 15 ng ml−1, was significantly decreased (P < 0.001) in comparison with age‐matched controls, whereas the mean IGF‐II level, 1024 ± 48 ng ml−1. was increased. A significant correlation (r = 0.70, P < 0.05) was found between IGF‐II and HbA1c levels. The mean morning level of IGFBP, 75 ± 17 ng ml−1, at the onset of the study, was increased threefold above that in age‐matched controls (P < 0.01). There was a significant correlation between IGFBP and blood glucose values (r = 0.66, P < 0.05). During CSII therapy a significant decrease (P < 0.05) of the IGFBP levels was seen in subjects with a decrease in glucose levels, whereas no change was observed in IGF levels. The findings of elevated IGF‐II and IGFBP levels and correlations between IGFBP and blood glucose concentration as well as IGF‐II and HbA1c levels in adolescents with IDDM indicate that both IGF‐II and IGFBP reflect a deranged metabolism caused by inadequate insulin administration.

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