DNA amplification and an unstable arginine gene in Streptomyces lividans 66
- 1 June 1984
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 195 (1-2) , 134-138
- https://doi.org/10.1007/bf00332735
Abstract
Summary Streptomyces lividans 66 produced spontaneous chloramphenicol-sensitive mutants (Cmls) at a frequency of about 1% of spores. The Cmls mutant strains were very unstable, giving Arg- mutants at frequencies of about 25% of spores. All the Arg- mutants had amplified a particular 5.75 kb DNA fragment into tandem repeats of 250–500 copies per chromosome.Keywords
This publication has 26 references indexed in Scilit:
- Cloning and Expression of the Tyrosinase Gene from Streptomyces antibioticus in Streptomyces lividansMicrobiology, 1983
- Plasmids, Recombination and Chromosome Mapping in Streptomyces lividans 66Microbiology, 1983
- Cloning Streptomyces genes for antibiotic productionTrends in Biotechnology, 1983
- A Conditional Aerial Mycelium-Negative Mutant Of Streptomyces Fradiae with Deficient Ornithine Carbamoyltransferase ActivityMicrobiology, 1983
- DNA cloning in Streptomyces: resistance genes from antibiotic-producing speciesNature, 1980
- DNA cloning in Streptomyces: a bifunctional replicon comprising pBR322 inserted into a Streptomyces phageNature, 1980
- Unstable Naturally Occurring Resistance to Antibiotics in StreptomycesJournal of General Microbiology, 1978
- Chloramphenicol Acetyltransferase-independent Chloramphenicol Resistance in Streptomyces coelicolor A3(2)Journal of General Microbiology, 1977
- Chloramphenicol Acetylation in StreptomycesJournal of General Microbiology, 1976
- Multiple transport systems for basic amino acid transport in streptomyces hydrogenansBiochimica et Biophysica Acta (BBA) - Biomembranes, 1973