Pharmacokinetic and pharmacodynamic evaluation of gelatin microcapsule containing piretanide in beagle dogs.

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Abstract
A sustained-release property of gelatin microcapsules of piretanide was evaluated by pharmacodynamic parameters. The gelatin microcapsules of piretanide showed long-lasting, slow-release properties, when compared with its ordinary tablet from in the plasma piretanide level, piretanide excretion rate, urine excretion rate and urinary electrolyte (Na+, K+, Cl-) excretion rate without any loss in diuretic and saluretic activities, which fully satisfied the criteria for a sustained-release preparation.

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