Studies of blood groups, genetic linkage, trait association, and chromosomal pattern in multiple sclerosis

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Abstract
Blood groups were studied in 34 of 35 siblings and in 6 of the parents 8 families in which more than one living member was affected with multiple sclerosis. In addition 6 individual patients were evaluated making 46 the total number studied of whome 23 had multiple sclerosis or retrobulbar neuritis. There was no evidence of genetic linkage or the existence of an association between multiple sclerosis and other inherited characteristics. The frequency of occurrence of blood groups differed from the expected rate in the general population but this was probably due to statistical variation. The chromosome pattern was studied in one patient and found to be normal. The study indicated that no relationship exists between multiple sclerosis and any of the common single gene inherited traits.