Hematological Recovery in the Mouse Following Single Doses of Gamma Radiation and Cyclophosphamide

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Abstract
The number of platelets, reticulo-cytes, erythrocytes, peroxidase-positive cells, and leukocytes in the peripheral blood was determined following the administration of single doses of either 300 and 500 rads of gamma-irradiation or 3 and 5 mg of cyclophosphamide to the mouse. At the same time, the number of colony-forming units (CFU) in the spleens and femoral marrows of the mice was determined. The time required for the cells in the peripheral blood and the CFU in the hematopoietic organs to return to their normal levels was prolonged following gamma-irradiation (14 to 18 days), whereas following cyclophosphamide the time interval was relatively short (5 to 10 days). The consequence of this difference in the time required for recovery of these cell populations with respect to the use of fractionated schedules of these agents in chemotherapy are examined.