Serum Albumin and Gamma-Globulin in Normal Human Gastric Juice

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Abstract
In 9 human subjects without gastrointestinal disease, I131-labeled human serum albumin was administered intravenously, and neutralized gastric juice was collected by oro-gastric aspiration following intragastric instillation of phosphate buffer. Contamination by saliva was minimized by continuous suction from the mouth. Albumin was always present in the gastric aspirate in a concentration range of 17-451 [mu]g/ml, constituting 2.3 to 37% of the total protein content of such aspirates. Estimates of the corresponding minimum 24-hour gastric outputs of albumin were 21-690 mg. Similar experiments were performed in 5 additional human subjects utilizing I131-labeled human serum -globulin. The concentration range of -globulin was 33-95 [mu]g/ml, constituting 0.8-7.0% of the total gastric aspirate protein. The corresponding minimum 24-hour gastric outputs of -globulin were 33-384 mg. Saliva aspirated concomitantly with gastric contents also contained these proteins, but not always in measurable amounts. Hence, saliva did not appear to be a significant source of the serum proteins found in the gastric aspirates.

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