Changes in Frequencies of Chromosomal Aberrations and Sister Chromatid Exchanges during Confluent Holding Recovery in X-irradiated Normal Human Diploid Fibroblasts
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 48 (4) , 597-602
- https://doi.org/10.1080/09553008514551651
Abstract
The time course of the changes in survival and cytogenetic damage was studied in X-irradiated cultures of human diploid fibroblasts before release from density-inhibition of growth. The frequency of chromosomal aberrations declined rapidly during the initial 2 h recovery interval in parallel with an enhancement in survival. The frequency of sister chromatid exchanges (SCE) increased during this interval reaching a maximum of 2 h, then declined. These changes are discussed in relation to previous observations on X-ray induced cytogenetic damage and malignant transformation in rodent cells under similar conditions.This publication has 15 references indexed in Scilit:
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