Infection by Human Immunodeficiency Virus — CD4 is Not Enough
- 14 November 1996
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 335 (20) , 1528-1530
- https://doi.org/10.1056/nejm199611143352011
Abstract
The interaction between the human immunodeficiency virus (HIV) and its cellular target once seemed fairly simple: the virus attached to the CD4 molecule on the cell surface, entered the cell, and began its replicative cycle.1 However, in the past few years, research has turned up surprising evidence that the virus can bind to cells by means of receptors other than CD4. These alternative receptors include galactosylceramide on brain and bowel cells and, when the virus has formed a complex with antibody, Fc receptors. Binding through Fc receptors can actually enhance viral infection.1 Recent studies of the early events in HIV . . .Keywords
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