Pulmonary fibrosis following low-dose 1,3-bis (2-chloro-ethyl)-1-nitrosourea (BCNU) therapy
- 15 March 1980
- Vol. 45 (6) , 1311-1314
- https://doi.org/10.1002/1097-0142(19800315)45:6<1311::aid-cncr2820450607>3.0.co;2-u
Abstract
Two women, 65 and 55 years old, with metastatic malignant melanoma, were treated with low doses of BCNU for a short period (six and three months, total dose 2500 and 2000 mg). Both patients developed pulmonary fibrosis, which was visible in postmortem examination. In the first woman, lesion, development was so widespread as to be considered responsible for death. Because chest x-ray before treatment was not abnormal, we consider BCNU capable of inducing the lesion.This publication has 8 references indexed in Scilit:
- Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapyCancer, 1978
- Pulmonary Fibrosis after Prolonged Therapy with 1,3-Bis (2-chloroethyl)-nitrosoureaChest, 1977
- Cyclophosphamide therapy and interstitial pulmonary fibrosisCancer, 1976
- Combination chemotherapy for disseminated malignant melanomaCancer, 1975
- Lung Disease Associated with Methotrexate TherapyAustralian and New Zealand Journal of Medicine, 1974
- 1,3-Bis(2-Chloroethyl)-1-Nitrosourea (Bcnu) And Other Nitrosoureas In Cancer Treatment: A ReviewAdvances in Cancer Research, 1973
- LATE EFFECTS OF IMMUNOSUPPRESSIVE ANTICANCER DRUGS1967