Multiple Epstein-Barr Virus Infections in Healthy Individuals
Open Access
- 1 June 2003
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (11) , 6546-6550
- https://doi.org/10.1128/jvi.77.11.6546-6550.2003
Abstract
We employed a newly developed genotyping technique with direct representational detection of LMP-1 gene sequences to study the molecular epidemiology of Epstein-Barr virus (EBV) infection in healthy individuals. Infections with up to five different EBV genotypes were found in two of nine individuals studied. These results support the hypothesis that multiple EBV infections of healthy individuals are common. The implications for the development of an EBV vaccine are discussed.Keywords
This publication has 66 references indexed in Scilit:
- Persistence of Immunity to Live Attenuated Varicella Vaccine in Healthy AdultsClinical Infectious Diseases, 2002
- Persistent Productive Epstein‐Barr Virus Replication in Normal Epithelial Cells In VivoThe Journal of Infectious Diseases, 2001
- Cytomegalovirus reinfection in young childrenThe Journal of Pediatrics, 1996
- Over five-year follow-up of Oka/Merck varicella vaccine recipients in 465 infants and adolescentsThe Pediatric Infectious Disease Journal, 1995
- The role of repetitive DNA sequences in the size variation of Epstein--Barr virus (EBV) nuclear antigens, and the identification of different EBV isolates using RFLP and PCR analysisJournal of General Virology, 1995
- Sequence variation in the Epstein--Barr virus latent membrane protein 1Journal of General Virology, 1994
- Detection of multiple 'Ebnotypes' in individual Epstein-Barr virus carriers following lymphocyte transformation by virus derived from peripheral blood and oropharynxJournal of General Virology, 1994
- Expression of B-Type Epstein-Barr Virus in HIV-Infected Patients and Cardiac Transplant RecipientsAIDS Research and Human Retroviruses, 1992
- A Transformation-Incompetent, Nuclear Antigen 2-Deleted Epstein-Barr Virus Associated with Replicative InfectionThe Journal of Infectious Diseases, 1991
- Observations on Childhood Infections with the Epstein-Barr VirusThe Journal of Infectious Diseases, 1970