Cytogenetic Effects of Contrast Media and Triiodobenzoic Acid Derivatives in Human Lymphocytes
- 1 October 1978
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 129 (1) , 199-203
- https://doi.org/10.1148/129.1.199
Abstract
Micronuclei counts in blood samples from 9 patients before and after angiocardiography confirmed previous results suggesting the diatrizoate contrast medium was largely responsible for the observed cytogenetic damage. To discover the agents in the medium causing the cytogenetic damage, human lymphocyte cultures were exposed to diatrizoate and to the monoamino- and diamino-derivatives of triiodobenzoic acid. The amino-derivatives are capable of inhibiting mitosis and inducing micronuclei and chromosome aberrations at lower concentrations than diatrizoate.This publication has 5 references indexed in Scilit:
- Effect of Radiation and Contrast Media on ChromosomesRadiology, 1977
- Radiosensitivity of Human Lymphocytes and ThymocytesRadiation Research, 1977
- The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- Proliferation of Human Lymphocytes in CultureNature, 1966
- In Vivo Effects of Diagnostic X-Irradiation on Human ChromosomesNew England Journal of Medicine, 1964