THE CATECHOL AMINE CONTENT OF THE ADRENAL MEDULLA OF THE RAT FOLLOWING RESERPINE-INDUCED DEPLETION

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Abstract
SUMMARY: A single intravenous injection of reserpine (15 mg/kg) into albino rats of the Wistar strain will produce a near complete depletion of adrenal medullary catechol amines within 24 hr. Following this change, pressor amines are resynthesized and stored by the chromaffin cells and reach normal levels after a period of 9–14 days. During the early part of this period noradrenaline is re-formed and stored more rapidly than adrenaline, and is present in greater than normal amounts in the regions of the medulla which are normally concerned with storing adrenaline. It is, therefore, possible that methylation of the primary amine may be a rate-limiting factor in adrenaline synthesis.

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