Abstract
There is no correlation between virulence in experimental animals and such physical properties of Semliki Forest virus (SFV) as rates of inactivation or electrophoretic and chromatographic distribution patterns. Changes in the surface properties of the virus can be induced in most strains of SFV by addition of polysaccharide derivatives during virus growth in chick embryo cells; these changes cause a variation in the pattern of infection in both chick embryo cells and mice.

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