Ergebnisse einjähriger lokaler Pindolol-Anwendung bei Weitwinkel-Glaukomen

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Abstract
In a randomized and controlled study the efficacy and safety of Pindolol eye drops 1% were compared with Timolol eye drops 0.5% in the treatment of open-angle glaucoma over a period of 6 mo. With the exception of some allergic reactions there was no difference between the 2 with regard to IOP [intraocular pressure] and the other parameters documented, such as pulse, blood pressure, visual acuity, refraction, diameter of pupils, tear production, visual field and biomicroscopic and ophthalmoscopic. The results of prolongation of treatment in the 33 patients of the Pindolol group from mo. 7-mo. 12 in an open-case study are reported. The effect on IOP after 12 mo. was no different from that after mo. 6. There was no difference with regard to pulse and blood pressure. Four patients had to discontinue the treatment, in 1 case owing to drug-related side effects on the lids and conjunctiva. The other parameters documented (visual acuity, visual field, refraction, diameter of pupils, tear production, corneal sensitivity and biomicroscopic and ophthalmoscopic examination) revealed no difference between the 1st and the 2nd 6 mo. A diminution of the effect of the drug on the level and duration of IOP was ruled out.

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