Synthesis and conformational analysis of a coumarinic acid‐based cyclic prodrug of an opioid peptide with modified sensitivity to esterase‐catalyzed bioconversion
- 1 April 2002
- journal article
- research article
- Published by Wiley in Chemical Biology & Drug Design
- Vol. 59 (4) , 183-195
- https://doi.org/10.1034/j.1399-3011.2002.1o983.x
Abstract
The coumarinic acid‐based cyclic DADLE (H‐Tyr‐D‐Ala‐Gly‐Phe‐D‐Leu‐OH) prodrug 1a exhibited more favorable physicochemical properties than did DADLE for permeation across the intestinal muco...Keywords
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