Permeability of the Blood-Brain Barrier in the Rat after Local Proton Irradiation
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Acta Radiologica: Oncology
- Vol. 21 (4) , 267-271
- https://doi.org/10.3109/02841868209134015
Abstract
Rats were irradiated laterally through the brain with 200 MeV protons. The beam was of circular cross-section with a diameter of 5 or 7 mm. The doses were 50, 70, 100 and 150 Gy. After irradiation the rats were examined several times by use of injected 99Tcm-pertechnetate. The uptake of the substance increased to a maximum after 20 to 30 days and then decreased to a normal level. Differences in maximum uptake with respect to dose were significant only for the smaller beam diameter.Keywords
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