Thy‐1‐specific helper T cells can provide intramolecular help, but can provide intermolecular help only if the phosphatidylinositol anchor of Thy‐1 is replaced by a membrane insert

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Abstract
We have investigated the ability of Thy‐1 to serve as a helper antigen in delivering intermolecular help. The parental Thy‐1 molecule, which is attached to the cell surface via a phosphatidylinositol anchor, failed to deliver intermolecular help for an antibody response to H‐2 alloantigens. This failure appears to be due to the phosphatidylinositol anchor since a Thy‐1 hybrid construct, which is expressed as a transmembrane cell surface molecule, can serve as helper antigen and deliver intermolecular help.

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