Chemische Aspekte der Penicillin‐Allergie: die direkte Bildung der Penicilloyl‐Determinanten aus Penicillin

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Abstract
The aminolysis of two penicillin‐like compounds which cannot form penicillenic acid has been studied: 6‐Aminopenicillanic acid (which is highly immunogenic) reacts directly with ε‐amino groups at pH 7,4 under CO2‐free conditions; the possible role of its polymerisation in this reaction remains to be studied. 6‐Dinitrophenylamino‐penicillanic acid reacts with εamino groups at pH 7,4 as fast as benzylpenicillin and other penicillins. Its immunogenicity in the rabbit is similar to that of benzylpenicillin.