Ketoconazole in experimental vaginal candidosis in rats
Open Access
- 1 November 1986
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 30 (5) , 771-773
- https://doi.org/10.1128/aac.30.5.771
Abstract
Rats in pseudoestrous were treated subcutaneously with ketoconazole at 25 mg/kg twice a day. In both uninfected and infected rats ketoconazole inhibited the cornification of the vaginal epithelium. Thus, ketoconazole, in addition to having an antifungal effect, may aid in the removal of candida by inhibiting the epithelial conditions suitable for hyphal invasion.This publication has 14 references indexed in Scilit:
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