Interference With Estrogen-induced Tissue Growth in the Chick Genital Tract by a Folic Acid Antagonist

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Abstract
Ingestion of the folic acid antagonist described by Franklin, Stokstad, and Jukes (1947) markedly reduced the tissue-growth response to maximally effective doses of diethylstilbestrol in the chick held on an otherwise normal stock diet. The data indicate that this antivitamin can reduce the formation of new tissue in an organ under maximal hormonal stimulation for rapid growth. The inhibition can be obtained in animals fed a natural grain diet, and this can be reversed by an excess of synthetic folic acid.