Multiple Myeloma after Phenytoin Therapy

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Abstract
A case of multiple myeloma in a 48 yr old woman treated with phenytoin for 55 mo. is reported. This association may be coincidental; the depressive effect of phenytoin on the immune responses could account for the occurrence of dysglobulinemia. This case points out the need for periodic examination of serum proteins in patients chronically treated with hydantoin derivatives.