Highly Sensitive Microbiosensor for Creatinine Based on the Combination of Inactive Polypyrrole with Polyion Complexes
- 1 February 1998
- journal article
- Published by The Electrochemical Society in Journal of the Electrochemical Society
- Vol. 145 (2) , 406-408
- https://doi.org/10.1149/1.1838277
Abstract
Potentiometric creatinine microsensors were fabricated by use of a composite film consisting of polyion complex (PIC), which contains creatinine iminohydrolase (CIH), and the electrochemically inactive polypyrrole (iPPy). The PPy/PIC‐CIH composite film electrode displayed potential response to creatinine concentration owing to a pH change occurring during the enzymatic reaction. The sensitivity was varied by using different polyions of the PIC. With poly‐L‐lysine and sebacic acid, the iPPy/PIC‐CIH electrode demonstrated a high sensitivity (29.8 mV decade−1) and a low detection limit , which allow one to monitor creatinine concentration in the physiological range.Keywords
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