A Note on the Oxidative Deamination of Isomers of 5-Hydroxytryptamine and Other Indolealkylamines
- 1 September 1960
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 12 (1) , 761-764
- https://doi.org/10.1111/j.2042-7158.1960.tb12743.x
Abstract
Monoamine oxidase from guinea pig tissues oxidises 4-hydroxy-tryptamine, 6-hydroxytryptamine and 7-hydroxytryptamine at about 50–70 per cent of the rate of 5-hydroxytryptamine. For the rat liver the relative rate of oxidation of 6-hydroxytryptamine is less. 5-Methoxytryptamine and tryptamine are substrates for amine oxidase as good as, or better than 5-hydroxytryptamine, whereas iso-5-hydroxytryptamine and iso-tryptamine are oxidised less readily than 5-hydroxytryptamine and tryptamine. 5-Hydroxy-β-hydroxy-NN-dimethyltryptamine(β-hydroxybufotenine) does not seem to be a substrate for amine oxidase from guinea pig kidney.Keywords
This publication has 1 reference indexed in Scilit:
- ISOLATION OF 5-METHOXYINDOLE-3-ACETIC ACID FROM BOVINE PINEAL GLANDS1Journal of the American Chemical Society, 1959