The Value of Certain Drugs, Especially Sulfa Drugs, in the Treatment of Furunculosis in Brook Trout, Salvelinus Fontinalis

Abstract
Furunculosis of salmonoid fishes is a dread epizootic disease caused by a general infection by Bacterium salmonicida. In this experiment, treatment was tried with sulfonamides and another drug, “furacin” or “2–20–99” (new drug). The four treatments first used were: (1) sulfamerazine, (2) sulfathiazole, and (3) furacin, each administered by being mixed with the food; and (4) furacin added to the water of the troughs. For assignment of treatments, the troughs containing fingerling brook trout, approximately 8 months old and running 30 to the pound, were grouped in four blocks of five troughs–three blocks of fingerlings with furunculosis, and one block of fingerlings of similar age and size but free from this disease. In each block, one trough received no medication. The various treatments were assigned to troughs by random selection. The block of healthy fish was to test for possible serious ill effects from any of the treatments, and was located some distance from the infected fish. Treatments were begun August 30, 1945, and those involving sulfamerazine and sulfathiazole were continued through 25 days. The furacin treatments, less promising than the sulfonamide treatments, were replaced by sulfanilamide and sulfadiazine, each in the food, on the sixteenth day. Furacin in the water was not beneficial but furacin in the food had some helpful effect. Results with sulfanilamide and sulfadiazine were not encouraging. Sulfathiazole seems to have been more beneficial than furacin, but decidedly less effective than sulfamerazine. The improvement with sulfamerazine was impressive. Mortality dropped rapidly within a few days, generally was light after a week, and within 2 weeks almost completely stopped. Through 25 days, the loss was 17 percent, as compared with 50 percent among the infected lots not receiving medication. The data indicate that 8 grams of sulfamerazine per day per 100 pounds of fish is sufficient, and that a considerably lower dose is at least beneficial. Until further information is available, 8 grams of sulfamerazine per day per 100 pounds of fish, to be continued for at least 6 days after mortality stops, is recommended.

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