THE EXCRETION OF 17-KETOSTEROIDS. I. NORMAL VALUES IN RELATION TO AGE AND SEX*

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Abstract
THE purpose of the present study has been to ascertain the range and average rates of excretion of 17-ketosteroids in the urine of normal subjects at various ages as determined by the rapid method (1) previously described. Such data should prove useful for appraising results obtained in the study of endocrinopathies by the now rather large group of investigators throughout the country who have manifested an interest in, and are using the “short” method (1). MATERIALS AND PROCEDURE More than 450 twenty-four hour specimens of urine from 120 individuals, 93 male and 27 female, were examined. In the majority of cases three, and often many more, determinations per individual were made. More than half of the subjects were without clinical evidence of any disease. A smaller proportion were considered “normal” although they had one of a variety of disorders of a nonendocrine nature, such as pulmonary emphysema, mild anemia, coronary sclerosis, or psychoneurosis. Five cases of well-controlled diabetes mellitus were also included as we have failed to find any significant variation from normal in the excretion of 17-ketosteroids in such subjects.

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