Cloning and nucleotide sequence of placental hGH-V cDNA
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Archives Internationales de Physiologie et de Biochimie
- Vol. 96 (1) , 63-67
- https://doi.org/10.3109/13813458809079626
Abstract
We have previously demonstrated the presence in human placenta and maternal serum of a GH variant, called human placental growth hormone (hPGH). We have also shown that the hGH-V gene is expressed at the placental level thus possibly coding for hPGH. The hGH-V cDNA has now been isolated from a λ 11 human placenta cDNA library. Its sequence has been determined which firmly establishes the GH-V gene mode of splicing as well as the GH-V protein structure. Our data give final evidence of placental hGH-V gene expression and reinforce the hypothesis of identity between the hGH-V protein and hPGH.Keywords
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