Inhibition of Adrenal Steroidogenesis by Glutethimide

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Abstract
Glutethimide, in relatively high concentrations inhibits corticosterone synthesis by the rat adrenal in vitro. This effect is demonstrable regardless of whether glutethimide is administered to the rat prior to removal of the adrenals or is added directly to the incubation fluid. The conversion of pregnenolone and of deoxycorticosterone to corticosterone by incubated adrenals is inhibited by glutethimide, indicating a block of 11β-hydroxylation. Glutethimide also suppresses 21-hydroxylation as evidenced by a reduced conversion of 11β-hydroxyprogesterone to corticosterone. Chronic treatment of the intact rat with glutethimide significantly lowers plasma corticosterone concentration but does not affect adrenal weight or cholesterol concentration.

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