Elastic fibres: histological correlation with orcein and a new monoclonal antibody, HB8

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Abstract
HB8 is a new monoclonal antibody, prepared against human lymphocytes, which was found to react with elastic fibers, possibly the microfibrillar component. Samples of normal human and animal [rabbit and mouse] skin and human skin from various pathological conditions were subjected to immunolabeling with HB8; alternate sections from each sample were stained by a standard orcein procedure. The individual fibers were clearly marked by the HB8 and this was confirmed by comparison with the standard elastic tissue stain. HB8 provides a new direct, practical and accurate method for the study of elastic tissue.