Urea Tolerance as a Molecular Adaptation of Elasmobranch Hemoglobins
- 4 October 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4158) , 57-59
- https://doi.org/10.1126/science.186.4158.57
Abstract
Urea is maintained at moderately high concentrations in the blood and tissues of marine elasmobranchs. Functional properties of the hemoglobins from several elasmobranch species are unaffected by urea concentrations as high as 5 molar. This insensitivity to urea, which is not observed with human hemoglobin, is accompanied by an increased sensitivity to sodium chloride.Keywords
This publication has 14 references indexed in Scilit:
- Elasmobranch hemoglobins: Dimerization and polymerization in various speciesComparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1975
- Clinical Trials of Therapy for Sickle Cell Vaso-occlusive CrisesJAMA, 1974
- Molecular Pathology of Human Haemoglobin: Stereochemical Interpretation of Abnormal Oxygen AffinitiesNature, 1971
- The Kinetics of Ligand Binding and of the Association-Dissociation Reactions of Human HemoglobinPublished by Elsevier ,1971
- Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of AllosteryNature, 1970
- Molecular Pathology of Human HaemoglobinNature, 1968
- Dissociation of Human CO-Hemoglobin by Urea, Guanidine Hydrochloride, and Other Reagents*Biochemistry, 1965
- Hemoglobin and MyoglobinAdvances in Protein Chemistry, 1964
- The Kinetics of the Urea Denaturation of Hemoglobin. I. Beef Oxyhemoglobin*Biochemistry, 1962
- SULFHYDRYL GROUPS AND THE STRUCTURE OF HEMOGLOBINThe Journal of general physiology, 1956