Experimental Shigella Infections. III. Sensitivity of Normal, Starved and Carbon Tetrachloride Treated Guinea Pigs to Endotoxin
- 1 February 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 103 (2) , 415-418
- https://doi.org/10.3181/00379727-103-25541
Abstract
Pretreatment of Hartley strain guinea pigs either by subcutaneous injection with carbon tetrachloride or by 4-day period of starvation renders them more susceptible to intravenously administered endotoxin. The LD50 for normal animals is in excess- of 1300 ug; for starved animals 52.8 ug and for carbon tetrachloride treated animals 4.2 ug. Distribution of Cr51 label of Cr51 tagged endotoxin in organs of normal animals which survive intravenous dose of 52 ug of endotoxin is the same as that in carbon tetrachloride treated animals which succumb following this challenge.Keywords
This publication has 2 references indexed in Scilit:
- EXPERIMENTAL SHIGELLA INFECTIONS: CHARACTERISTICS OF A FATAL INFECTION PRODUCED IN GUINEA PIGSJournal of Bacteriology, 1958
- Hypotension (Shock) in Dogs Produced by Escherichia coli EndotoxinCirculation Research, 1956