Immune Complex Disease in the Kidneys of Lymphoma-Leukemia Patients: The Presence of an Oncornavirus-Related Antigen2
Open Access
- 1 March 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 50 (3) , 633-644
- https://doi.org/10.1093/jnci/50.3.633
Abstract
Subclinical glomerular immune complex disease was found in 9 of 94 kidneys obtained post mortem from patients with lymphoma and leukemia. The incidence was highest in patients with acute myelocytic leukemia (16%) and lowest in patients with solid lymphoreticular malignancies (3%). Evidence was obtained that an antigen related to the interspecies (gs-3) antigen of mammalian oncornaviruses was present in the kidneys of 2 patients with acute myelocytic leukemia. The high incidence of immune complex disease in kidneys from patients with acute leukemia, as well as the presence of the gs-3 antigen in 2 of these patients, parallels experience demonstrating the presence of this disease in AKR mice and suggests homology in the etiology of human and murine leukemia.Keywords
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