Partial characterization of synovial fluid nucleotide pyrophosphohydrolase

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Abstract
Synovial fluid adenosine triphosphate pyrophosphohydrolase, an enzyme which manifests increased activity in chondrocalcinosis and osteoarthritis, was partially characterized in synovial fluids from 41 patients who had a variety of arthropathies. Activity was found to be a soluble, heat labile, and divalent cationdependent nonspecific nucleotide pyrophosphohydrolase with pH optimum 9.0–9.5.