Studies on the synthesis of the antitumour agent CC-1065. Synthesis of the cyclopropapyrroloindole portion
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 6,p. 389-390
- https://doi.org/10.1039/c39840000389
Abstract
Using a regioselective Mannich reaction the 3,3′-bipyrrole (4) is converted into the acid chloride (10), which is transformed into the tricyclic phenol (11); selective reduction of (11) using triethylsilane in trifluoroacetic acid gives (12), which is converted by further reduction into (14), which by the intermolecular Mitsunobo reaction gives the cyclopropapyrroloindole (17).Keywords
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