Effect of Diet on Urinary Excretion of Histamine

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Abstract
The 24-hr. output of free and conjugated histamine in the urine of 5 healthy adults was measured while they ate a mixed diet for 3 days, then fasted for 3 days, then took bread and milk for 2 days, and finally ate a diet composed principally of meat for 3 days. In another series of observations on 3 adults the output of free and conjugated histamine for 2-hr. periods was followed after the ingestion of 60 mg. of histamine, after the ingestion of a meal of milk, bread and butter, and after the histamine and the meal were taken together. Fasting always reduced the daily excretion of both free and conjugated histamine. The free form fell to a basal and rather fixed output, which may be an index of total histamine metabolism independent of digestion. The taking of bread and milk did not alter the output of free histamine in the urine from the fasting or basal level. A diet of meat always increased it. The output of conjugated histamine in the urine was also increased by the ingestion of meat. In general, its output was subject to much more sweeping changes than occurred in the output of free histamine. No change occurred in the output of free histamine in the urine at 2-hour intervals when histamine was taken by mouth or when a meal of milk, bread and butter was eaten, but a large increase occurred when the 2 were taken together.

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