ON HISTIDINURIA

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Abstract
1. L‐histidine was given intravenously and orally to pregnant and non‐pregnant women, and was estimated in the blood by a modified diazo reaction and by its reaction with bromine in the urine.2. On intravenous as well as on oral application, L‐histidine disappeared only very slowly from the blood‐stream of pregnant women as compared with non‐pregnant women, large amounts of it being simultaneously excreted in the urine. This observation does not confirm the results of Page, who found that on intravenous injection L‐histidine leaves the blood‐stream of pregnant women at least as quickly as that of non‐pregnant persons. It seems, moreover, to support the previously suggested theory of a reduced activity of histidase in human pregnancy.3. In severe toxæmia of pregnancy no histidine could be detected in the urine even after the injection or ingestion of histidine although the blood levels remained high. This indicates a retention of L‐histidine by the kidney.4. The results obtained in mild pregnancy toxæmia were intermediate between those found in severe toxæmia and in normal pregnancy.

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